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慢性感觉性或感觉运动性多发性神经病是转诊给神经内科的一种常见疾病。尽管有患者接受了很多项辅助检查,仍有约1/3的患者病因不明。这些患者诊断为隐源性感觉性多发性神经病(CSPN),发病年龄不一,多在60~70岁,男女性别间患病率差异无显著性。CSPN临床症状进展缓慢,大多数患者表现为肢体远端感觉异常或疼痛,数年之后可累及双手。进一步检查可能会发现趾背屈和背伸力弱,神经电生理和组织学检查提示轴索性神经病变。CSPN预后通常良好,大部分病例可以保持独立行走能力。除对患者进行相关的教育和心理安慰外,主要的治疗措施有神经性疼痛治疗、平衡训练等物理治疗以及使用辅助装置等。
Chronic sensory or motor sensitization Polyneuropathy is a common disease referred to neurology. About 1/3 of the patients still have unknown etiology, despite the many patients who have undergone ancillary examinations. These patients diagnosed as cryptogenic sensory polyneuropathy (CSPN), the age of onset varies, mostly in the 60 to 70 years old, no significant difference in the prevalence between men and women. Clinical symptoms of CSPN progress slowly, most patients showed abnormal sensory or distal limb pain, after a few years may involve both hands. Further examination may reveal weak toe dorsiflexion and dorsiflexion, and neurophysiological and histological findings suggest axonal neuropathy. The prognosis for CSPN is usually good, and in most cases the ability to walk independently can be maintained. In addition to the patient’s related education and psychological comfort, the main treatment measures are neuropathic pain treatment, balance training and other physical therapy and the use of auxiliary devices.