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目的:探讨慢性乙型肝炎患者肝组织免疫组化表达与血清HBV DNA、HBeAg的关系。方法:检测120例慢性乙型肝炎患者外周血HBV DNA、HBeAg含量,同时观察肝组织内免疫组化检测HBsAg、HBcAg的表达,并分析二者之间的关系。结果:120例慢乙肝患者血清HBsAg全阳性,HBeAg阳性58例,HBVDNA阳性72例,肝组织内免疫组化HBsAg阳性120例,HBcAg阳性64例,各组间比较差别均有统计学意义(P<0.05)。结论:慢性乙型肝炎病毒复制指标血清HBV DNA、HBeAg及肝组织内HBcAg中HBcAg表达更能反映出肝内乙肝病毒复制状况。
Objective: To investigate the relationship between the expression of serum HBV DNA and HBeAg in the liver tissues of patients with chronic hepatitis B Methods: The levels of HBV DNA and HBeAg in peripheral blood of 120 patients with chronic hepatitis B were detected. Meanwhile, the expression of HBsAg and HBcAg in liver tissue were detected by immunohistochemistry and the relationship between them was analyzed. Results: Serum HBsAg was positive in 120 patients with chronic hepatitis B, with 58 cases of HBeAg positive, 72 cases of HBVDNA positive, 120 cases of HBsAg immunohistochemistry in liver and 64 cases of HBcAg positive. There were significant differences among the groups (P <0.05). Conclusion: The expression of HBcAg in HBV DNA, HBeAg and HBcAg in liver tissue of chronic hepatitis B virus replication index can better reflect the intrahepatic hepatitis B virus replication status.