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目的探讨盐酸羟考酮缓释片联合盐酸吗啡针滴定癌痛的疗效及不良反应。方法 90例住院中重度癌痛患者应用盐酸羟考酮缓释片联合吗啡针滴定,记录滴定完成所需要的时间,观察滴定开始后第7天的疼痛控制有效率,滴定前、后的疼痛强度变化以及滴定中的不良反应。疼痛强度评分应用数字分级法。结果 87.8%的患者在3天内完成滴定。滴定后第7天患者疼痛控制率达96.7%。滴定中不良反应主要为便秘(27.8%)、恶心呕吐(13.3%)、嗜睡(4.4%),除便秘外经过对症处理均可耐受。结论盐酸羟考酮缓释片联合吗啡针滴定中重度癌痛患者达到良好滴定效果,不良反应较轻。
Objective To investigate the efficacy and side effects of oxycodone hydrochloride sustained-release tablets in combination with morphine needle for titration of cancer pain. Methods Ninety patients with moderate-to-severe cancer pain were treated with oxycodone hydrochloride sustained-release tablets combined with morphine needle titration. The time required for titration was recorded. The effective rate of pain control, the pain intensity before and after titration, Changes and adverse reactions in titration. Pain intensity score using digital grading. Results 87.8% of the patients completed the titration within 3 days. On the seventh day after titration, the pain control rate reached 96.7%. Adverse reactions in titration were mainly constipation (27.8%), nausea and vomiting (13.3%), drowsiness (4.4%), except symptomatic treatment of constipation can be tolerated. Conclusion Oxycodone hydrochloride sustained-release tablets combined with morphine needle titration in patients with moderate to severe cancer titration to achieve good titration effect, mild adverse reactions.