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目的探讨瞬时弹性成像技术(FibroScan)、谷草转氨酶/血小板(APRI)及透明质酸(HA)在慢性乙型肝炎患者肝纤维化诊断中的价值。方法比较分析符合条件的250例慢性乙肝肝炎患者肝硬度、APRI、HA单项及联合诊断模型对肝纤维化诊断效果,并分别绘制ROC曲线。结果肝硬度、APRI、HA单项及三项联合对S2~S4期肝纤维化诊断的曲线下面积分别为0.73、0.71、0.51及0.78;对S3~S4期的患者曲线下面积分别为0.79、0.62、0.78及0.85;对S4期的患者曲线下面积分别为0.81、0.52、0.75及0.81。结论肝硬度、APRI、HA三项指标联合可提高各期慢性乙型肝炎患者肝纤维化诊断效果,在肝纤维化的动态监测上有一定的临床应用价值。
Objective To investigate the value of FibroScan, APT and HA in the diagnosis of liver fibrosis in patients with chronic hepatitis B. Methods A comparative analysis of 250 patients with chronic hepatitis B liver cirrhosis, APRI, HA single and combined diagnostic model of liver fibrosis diagnosis, and were drawn ROC curve. Results The area under the curve of hepatic stiffness, APRI, HA single and triple combination for diagnosis of S2 ~ S4 liver fibrosis were 0.73,0.71,0.51 and 0.78, respectively. The area under the curve of patients with S3 ~ S4 was 0.79,0.62 , 0.78 and 0.85, respectively. The area under the curve of patients with S4 was 0.81, 0.52, 0.75 and 0.81, respectively. Conclusions The combination of liver stiffness, APRI and HA can improve the diagnosis of liver fibrosis in patients with chronic hepatitis B, and has certain clinical value in the dynamic monitoring of liver fibrosis.