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本文研究了喃氟啶软膏剂对小白鼠和裸鼠离休皮肤的透皮吸收。比较了小白鼠和裸鼠皮肤渗透性、药物浓度和透皮吸收促进剂对喃氟啶透皮吸收的影响。实验结果表明，小白鼠皮肤对喃氟啶渗透性大于裸鼠皮肤，采用透皮吸收促进剂和提高药物浓度可大大提高药物的透皮吸收速率。本研究为临床用药和配制喃氟啶软膏剂选择适宜药物浓度和促进剂浓度提供了依据。
In this paper, the transdermal absorption of fuflunomide ointment on rejuvenated skin of mice and nude mice was studied. The effects of skin permeability, drug concentration and transdermal absorption enhancer on the transdermal absorption of doxofluid were compared between mice and nude mice. The experimental results show that the skin permeability of mice is greater than that of nude mice, and the transdermal absorption rate of the drug can be greatly improved by using the transdermal absorption enhancer and increasing the drug concentration. This study provides a basis for clinical drug and preparation of fufangdine ointment to choose the appropriate drug concentration and concentration of accelerator.