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精神分裂症的遗传倾向提示其部分病因是在基因上，而多巴胺假说又是解释精神分裂症病因机制的主要生化假说，二者提示精神分裂症与多巴胺受体基因可能存在重要的联系。本文对近年有关精神分裂症及氯氮平疗效与Ｄ４受体基因之间关系的研究作一综述。
The genetic predisposition to schizophrenia suggests that some of its etiology is genetically, whereas the dopamine hypothesis is another major biochemical hypothesis that explains the etiopathogenisis of schizophrenia. Both suggest that schizophrenia may have an important connection to the dopamine receptor gene. This review summarizes recent studies on the relationship between schizophrenia and clozapine efficacy and the D4 receptor gene.