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目的观察怡心健脑颗粒对老年痴呆症(AD)小鼠学习记忆及抗氧化能力的影响。方法运用D-半乳糖合β-AP25-35诱导小鼠AD模型,水迷宫法观察怡心健脑颗粒对AD小鼠学习记忆成绩的影响,并测定小鼠血清、肝脏与脑组织中丙二醛(MDA)、超氧化歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽(GSH)的含量。结果与对照组比较,模型组AD小鼠的学习记忆成绩明显下降,其血清、肝脏及脑组织中MDA含量明显升高,SOD、GSH、GSH-Px含量明显下降;与模型组比较给药组AD小鼠的学习记忆成绩明显提高,血清、肝脏及脑组织中SOD、GSH、GSH-Px含量明显升高,MDA含量降低。结论怡心健脑颗粒对D-半乳糖合β-AP25-35诱导的AD小鼠具有健脑益智药理作用,并能提高其抗氧化能力。
Objective To observe the effects of Yixin Jiannao granule on learning and memory and antioxidant capacity in mice with Alzheimer’s disease (AD). Methods The AD model was induced by D-galactose and β-AP25-35. The effect of Yixin Jiannao granule on learning and memory of AD mice was observed by water maze test. Aldehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione (GSH) content. Results Compared with the control group, the learning and memory scores of AD mice in model group decreased significantly, and the contents of MDA, SOD, GSH and GSH-Px in serum, liver and brain tissue were significantly increased. Compared with model group, AD mice significantly improved learning and memory performance, serum, liver and brain tissue SOD, GSH, GSH-Px levels were significantly increased, MDA content decreased. Conclusion Yixinjiannao granule has brain-strengthening and pharmacological effects on D-galactose-induced β-AP25-35 AD mice, and can improve its anti-oxidative capacity.