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目的:通过标准化检测技术对全国多地区表观健康老年人血小板聚集功能进行调研，分析我国表观健康老年人群血小板聚集功能特点及与年龄相关参考区间，以促进抗血小板药物的合理应用。方法:2018年1月至2019年8月，纳入全国6家三甲医院≥60岁表观健康老年人共5 658名，通过标准化的全自动血小板聚集仪对纳入对象分别进行花生四烯酸（AA）和二磷酸腺苷（ADP）诱导的血小板聚集率检测，并分析60~69、70~79和80~90岁年龄段AA和ADP诱导的血小板聚集率，根据CLSI C28-A3使用的非参数方法定义参考区间（以n P2.5和n P97.5确定95%置信区间）。n 结果:采用标准化的血小板检测技术，各医院间AA和ADP诱导的血小板聚集率比较，差异均无统计学意义（n P均>0.05）。5 658名中2 633名（46.54%）行AA诱导的血小板聚集率检测，70~79、 80~90岁老年人AA诱导的血小板聚集率高于60~69岁［（72.35±11.67）%、（72.67±11.45）%比（70.65±12.57）%，n P均70岁老年人群单独建立血小板聚集率参考区间，而ADP诱导的血小板聚集率不需单独建立老年血小板聚集率参考范围。“,”Objective:To promote the rational use of antiplatelet drugs by analyzing the characteristics of platelet aggregation function through the standardized detection technology, and determining the association between platelet aggregation function and age in apparently healthy elderly Chinese.Methods:In this study, 5 658 apparently healthy elderly participants aged ≥60 years were enrolled from 6 hospitals between January 1, 2018 and August 31, 2019. The platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was detected by a standardized automatic platelet aggregation instrument, and the platelet aggregation rate induced by AA and ADP among various age groups (60-69, 70-79 and 80-89 years) was analyzed. Reference intervals were defined according to CLSI document C28-A3 using the nonparametric method (n P2.5 and n P97.5 were used to determine the 95% confidence interval).n Results:The platelet aggregation rates induced by AA and ADP was similar between hospitals by standardized platelet detection techniques (all n P>0.05). Among 5 658 patients, 2 633 (46.54%) received AA-induced platelet aggregation test, and the AA-induced platelet aggregation rate was significantly higher in the 70-79 and 80-90 years groups than that in the 60-69 years group ([72.35±11.67]% and [72.67±11.45]% vs [70.65±12.57]%, alln P<0.001), while which was similar between the 70-79 years and 80-90 years groups (n P=0.840). ADP-induced platelet aggregation rate was detected in 3 025 participants (53.46%), and there was no statistically significant difference among all age groups (n P=0.654). The recommended reference interval for AA-induced platelet aggregation was 37.12%-88.47% for people aged 60-69 years, and 37.45%-88.97% for people aged 70-90 years. The recommended reference interval for ADP-induced platelet aggregation rate is 47.95%-92.11%.n Conclusions:The results of platelet aggregation are consistent across laboratories using standardized testing systems through standardized testing procedures. It is necessary to establish a reference range for the platelet aggregation rate induced by AA in the elderly people aged 60-69 and older than 70 years, while the platelet aggregation rate induced by ADP does not require a separate reference range for the platelet aggregation rate in the elderly.