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采用水提法获得木耳(Auricularia auricula)提取物和余渣,并借助中药清肺润肺小鼠模型研究它们的止咳化痰功效。结果表明:提取物和余渣得率分别为12.3%和71.6%;3 min内提取物高剂量组(200mg/kg·d)咳嗽次数为(7.67±3.28),余渣高剂量组咳嗽次数为(7.75±3.28),两者与空白对照组咳嗽次数(21.25±3.37)之间均存在极显著性差异(P<0.01),说明提取物和余渣都有显著的止咳作用;虽然提取物和余渣的小鼠酚红排泌量增加幅度均高于阳性对照组,但仅余渣高剂量组与阳性对照组之间存在显著性差异(P<0.05),说明余渣化痰效果优于提取物。
Water extract was used to obtain the extract of Auricularia auricula and the residue, and their lung-cough and phlegm-resolving effects were studied with the Chinese herbal formula Qingfei Runfei. The results showed that the yields of extract and residue were 12.3% and 71.6%, respectively. The number of coughs in high dose group (200mg / kg · d) within 3 min was (7.67 ± 3.28) and the number of cough in high- (7.75 ± 3.28). There was a significant difference between the two groups (21.25 ± 3.37) and control group (P <0.01), which indicated that both extract and residue had significant antitussive effect. Although extract and Residues of mouse phenol red excretion increased more than the positive control group, but only the residual high-dose group and the positive control group there was a significant difference (P <0.05), indicating residual phlegm better than Extract.