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目的探讨小剂量地塞米松在脑梗死急性期的治疗作用。方法 120例脑梗死患者随机分为地塞米松治疗组、安慰剂组及对照组,对照组只给予常规治疗,地塞米松治疗组为常规治疗+1mL(5mg)地塞米松注射液,安慰剂组则为常规治疗+1mL注射用水,各组分别于治疗后1个月及3个月行血常规及红细胞沉降率检查,同时采用Barthel指数及改良Rankin量表对受试对象进行神经功能评定。结果地塞米松治疗组红细胞沉降率较安慰剂组及对照组明显减慢,差异有统计学意义(P<0.05)。根据Barthel指数及改良Rankin量表评定结果,地塞米松治疗组神经功能明显改善,较安慰剂组及对照组明显增加,差异有统计学意义(P<0.05)。结论小剂量地塞米松在脑梗死急性期发挥了神经保护作用。
Objective To investigate the therapeutic effect of low dose dexamethasone in the acute stage of cerebral infarction. Methods One hundred and twenty patients with cerebral infarction were randomly divided into dexamethasone treatment group, placebo group and control group. The control group was given routine treatment only. Dexamethasone treatment group was given routine treatment plus dexamethasone 1 mL (5mg), placebo The rats in the control group were given routine treatment and 1 mL of water for injection. The blood routine and erythrocyte sedimentation rate were examined at 1 month and 3 months after treatment. The neurological function of the subjects was evaluated by Barthel index and modified Rankin scale. Results Dexamethasone treatment group erythrocyte sedimentation rate was significantly slower than placebo and control group, the difference was statistically significant (P <0.05). According to the results of Barthel index and modified Rankin scale, the neurological function of dexamethasone group was significantly improved compared with placebo group and control group, the difference was statistically significant (P <0.05). Conclusion Low-dose dexamethasone exerts neuroprotective effect in acute stage of cerebral infarction.