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目的探讨血清肿瘤坏死因子α(TNF α)水平与 2型糖尿病胰岛素抵抗、冠心病之间的关系。方法分别应用氧化酶法、放射免疫双抗体法和酶联免疫吸附法测定 48例 2型糖尿病并冠心病患者及 42例健康人的空腹血糖 (FBG)、血清胰岛素 (FINS)及TNF α值 ,计算胰岛素敏感性指数(ISI)。结果病例组TNF α与FINS、FBG呈正相关。结论胰岛素抵抗程度与TNF α水平升高密切相关 ,二者相互影响、相互促进 ,共同参与2型糖尿病患者大血管病变的发生与发展过程。
Objective To investigate the relationship between serum tumor necrosis factor α (TNF α) and type 2 diabetes with insulin resistance and coronary heart disease. Methods 氧 The fasting blood glucose (FBG), serum insulin (FINS) and TNFα (TNFα) in 48 type 2 diabetic patients with coronary heart disease and 42 healthy people were measured by enzyme-linked immunosorbent assay, radioimmunoassay and enzyme- Value, calculate the insulin sensitivity index (ISI). Results In the case group, TNFα was positively correlated with FINS and FBG. Conclusion Insulin resistance is closely related to the elevated level of TNFα, both of them interact and promote each other, and participate in the occurrence and development of macrovascular disease in type 2 diabetic patients.