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过去28个月中,22个医疗中心将373例因左半结肠癌或憩室病而择期作左结肠切除并吻合术的病人随机分为4组:Ⅰ组(对照组)100例,以水灌肠,术前12小时口服甲硝唑1.5g,自手术开始时每天静脉滴注甲硝唑1.5g,青霉素G 1千万IU,共3天;Ⅱ组(95例)、Ⅲ组(85例)和Ⅳ组(93例)均于手术前晚及术前2小时作聚烯吡酮碘灌肠(2升),手术开始时静滴抗生素计24小时:Ⅱ组用甲硝唑1.5g,Ⅲ组用头孢噻肟4g,Ⅳ组用头孢噻肟加甲硝唑。所有病人均于手术前晚口服番泻叶浓缩液。
In the past 28 months, 22 medical centers randomly divided 373 patients who underwent left colon resection and anastomosis due to left-sided colon cancer or diverticular disease into 4 groups: group Ⅰ (control group), 100 cases of water enema , 12 hours before operation, oral metronidazole 1.5g, intravenous infusion of metronidazole 1.5g, penicillin G 10 million IU daily for 3 days since the beginning of the operation; group Ⅱ (95 cases), group Ⅲ (85 cases) And group IV (n = 93) were given povidone-iodine enema (2 liters) two hours before surgery and two hours before operation. Antibiotics were intravenously administered for 24 hours at the beginning of operation: group I was treated with 1.5 g metronidazole, Cefotaxime 4g, Ⅳ group with cefotaxime plus metronidazole. All patients were orally administered senna concentrate before surgery.