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目的研究癌胚抗原相关细胞黏附分子6(carcinoembryonic antigen related cell adhesion molecule 6,CEACAM6)蛋白在肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达及其与临床病理参数的关系。方法采用免疫组织化学S-P法检测62例肝细胞癌、18例肝炎肝硬化、10例肝海绵状血管瘤组织中CEACAM6蛋白的表达,并分析其与肝细胞癌的临床病理参数的关系。结果在肝炎肝硬化、肝海绵状血管瘤组织中未见CEACAM6蛋白表达,在肝细胞癌组织中CEACAM6蛋白的阳性表达率为69.4%(43/62),与肝炎肝硬化、肝海绵状血管瘤组相比,差异有统计学意义(P<0.01,χ2=31.2)。肝细胞癌组织中CEACAM6蛋白的表达与肿瘤分期、门静脉癌栓、肿瘤包膜等临床病理学参数明显相关(P<0.01)。结论肝细胞癌组织中CEACAM6蛋白的表达与肿瘤发生、发展和侵袭转移明显相关,CEACAM6可能是防治肝细胞癌及其侵袭转移的有效靶点。
Objective To investigate the expression of carcinoembryonic antigen related cell adhesion molecule 6 (CEACAM6) in hepatocellular carcinoma (HCC) and its relationship with clinicopathological parameters. Methods Immunohistochemical S-P method was used to detect the expression of CEACAM6 in 62 cases of hepatocellular carcinoma, 18 cases of hepatic cirrhosis and 10 cases of hepatic cavernous hemangioma. The relationship between the expression of CEACAM6 and clinicopathological parameters of hepatocellular carcinoma was analyzed. Results There was no CEACAM6 protein expression in hepatic cirrhosis and hepatic cavernous hemangioma. The positive expression rate of CEACAM6 protein in hepatocellular carcinoma was 69.4% (43/62), which was correlated with liver cirrhosis, hepatic cavernous hemangioma Group, the difference was statistically significant (P <0.01, χ2 = 31.2). The expression of CEACAM6 in hepatocellular carcinoma was significantly correlated with clinicopathological parameters such as tumor stage, portal vein tumor thrombus and tumor capsule (P <0.01). Conclusion The expression of CEACAM6 protein in hepatocellular carcinoma is closely related to tumorigenesis, development and invasion and metastasis. CEACAM6 may be an effective target for prevention and treatment of hepatocellular carcinoma and its invasion and metastasis.