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目的观察高龄胃肠肿瘤患者术中腹腔区域性缓释化疗的近期安全性及使用效果。方法将36例高龄肿瘤患者分为治疗组17例和对照组19例,两组常规行肿瘤根治术,治疗组术中在瘤床和沿淋巴引流途径多点植入氟尿嘧啶缓释剂共600mg。观察两组不良反应、安全性及近期疗效。结果与对照组比较,治疗组局部复发率降低(P<0.05),术后白细胞计数与术前相比亦升高(P<0.05)。结论高龄胃肠肿瘤患者术中应用区域性缓释化疗安全可行,对预防局部复发有一定作用。
Objective To observe the recent safety and efficacy of intra-abdominal peritoneal chemotherapy in elderly patients with gastrointestinal cancer. Methods Thirty-six patients with advanced cancer were divided into treatment group (n = 17) and control group (n = 19). The two groups were treated with radical nephrectomy. In the operation group, 600 mg of fluorouracil sustained-release agent was implanted in the tumor bed and lymphatic drainage. Two groups of adverse reactions, safety and short-term efficacy were observed. Results Compared with the control group, the local recurrence rate of the treatment group decreased (P <0.05), and the postoperative leukocyte count also increased compared with that before operation (P <0.05). Conclusion The application of regional sustained-release chemotherapy in elderly patients with gastrointestinal cancer is safe and feasible, and has a certain effect on the prevention of local recurrence.