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[目的]探讨伽玛刀放射外科治疗脑膜瘤的效果及其影响因素。[方法]选取我院伽玛刀中心2007年3月～2009年3月期间85例接受伽玛刀治疗的脑膜瘤患者。根据治疗前后的临床表现、影像学资料进行评估。[结果]随访时间3～24个月,肿瘤消失14例(16.5%),缩小53例(62.3%),无变化10例(11.8%),增大8例(9.4%),肿瘤控制率为90.6%。肿瘤的病理类型、部位与体积对肿瘤控制率的高低有显著影响,而年龄、性别、手术史和边缘剂量等对肿瘤控制率影响不大。[结论]伽玛刀是一种治疗脑膜瘤安全有效的方法,是外科手术的有益补充。尤其是颅底深部、难以手术全切除,或术后残留、复发,或年老体弱不宜手术者,首选伽玛刀可以获得理想的疗效。
[Objective] To explore the effect of gamma knife radiosurgery on meningiomas and its influencing factors. [Methods] Totally 85 patients with meningiomas undergoing gamma knife treatment from March 2007 to March 2009 in our hospital were selected. According to the clinical manifestations before and after treatment, imaging data were evaluated. [Results] The tumor disappeared in 14 cases (16.5%), reduced in 53 cases (62.3%), unchanged in 10 cases (11.8%) and increased in 8 cases (9.4%) with the follow-up time of 3-24 months. The tumor control rate was 90.6%. The pathological type, location and volume of the tumor have a significant impact on the rate of tumor control, while age, sex, history of surgery and edge dose have little effect on tumor control rate. [Conclusion] Gamma Knife is a safe and effective method to treat meningiomas and is a good supplement for surgery. In particular, deep skull base, difficult surgery, total resection, or postoperative residual, recurrence, or frail elderly patients should not surgery, the preferred gamma knife can get the desired effect.