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目的:观察氨酚羟考酮联合卡马西平治疗带状疱疹后遗神经痛(postherpetic neuralgia,PNH)的疗效和安全性。方法:90名PHN患者随机分为氨酚羟考酮组(A组,n=45)和氨酚羟考酮片联合卡马西平联合治疗组(B组,n=45),治疗4周。观察各治疗组治疗前后疼痛缓解强度(VAS评分)变化、镇痛有效率及不良反应。结果:联合治疗组的镇痛显效率高于氨酚羟考酮组(P<0.05);两组的药物不良反应主要表现为头晕、嗜睡、恶心、呕吐,不良反应的总发生率无显著差异。结论:氨酚羟考酮联合卡马西平治疗PHN,镇痛效果良好,安全可靠,是PHN止痛可供选择的措施之一。
Objective: To observe the efficacy and safety of oxycodone and carbamazepine in the treatment of postherpetic neuralgia (PNH). Methods: Ninety patients with PHN were randomized to receive oxycodone (group A, n = 45) and oxycodone plus carbamazepine (group B, n = 45) for 4 weeks. The changes of pain relief intensity (VAS score), analgesic efficiency and adverse reactions before and after treatment in each treatment group were observed. Results: The analgesic efficiency of combination therapy group was higher than that of oxycodone oxycodone group (P <0.05). There was no significant difference of adverse reactions between two groups in the incidence of dizziness, drowsiness, nausea and vomiting . Conclusion: Paracetamol and oxymatrine combined with carbamazepine in the treatment of PHN have a good analgesic effect and are safe and reliable, which is one of the available options for analgesia of PHN.