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慢性乙型肝炎是肝硬化和肝细胞癌的高危因素,目前世界范围内有近4亿的慢性乙型肝炎病毒(HBV)携带者,HBV感染已成为世界性的公共卫生问题。近年来乙型肝炎的治疗虽取得了长足的进展,但在停药后的复发等一系列问题上,一直是困扰临床医务工作者的难题。现已研究证实乙型肝炎病毒共价闭合环状DNA(HBV cccDNA)在HBV复制的过程中起关键作用,它的存在与乙型肝炎慢性化之间有着重要的联系。因此cccDNA成为近年的研究热点,对于
Chronic hepatitis B is a high risk factor for cirrhosis and hepatocellular carcinoma. Currently there are nearly 400 million carriers of chronic hepatitis B virus (HBV) in the world. HBV infection has become a worldwide public health problem. In recent years, despite the considerable progress made in the treatment of hepatitis B, it has always been a problem that has plagued clinical medical workers for a series of problems such as recurrence after drug withdrawal. It has been confirmed that hepatitis C virus covalently linked circular DNA (HBV cccDNA) plays a key role in the process of HBV replication, and its existence is closely related to the chronicity of hepatitis B infection. Therefore, cccDNA has become a hot research topic in recent years