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目的分析四川省3例人禽流感病例特点,为防治提供科学依据。方法按照《人禽流感流行病学调查方案》,对病例进行个案调查,调查发病经过、治疗情况,实验室检测,可能的感染来源,传播途径及暴露因素等。结果3例人禽流感病例初期临床表现主要为流感样症状,2例病例的气管分泌物分离出禽流感病毒H5N1,1例病例的气管分泌物禽流感病毒H5N1核酸阳性,3例病例咽拭子样核酸均为阴性。1例病例未发现明确的病死禽接触史;2例虽有明确的病死家禽接触史,但死禽未被证实感染禽流感病毒。结论3例病例均为实验室确诊病例;应尽量采集患者的气管分泌物样进行检测;对人禽流感病例的诊断不能完全依据禽流感疫情存在与否;人禽流感的感染来源、传播途径和影响因素等问题尚待进一步研究。
Objective To analyze the characteristics of 3 cases of bird flu in Sichuan Province and provide a scientific basis for prevention and treatment. Methods According to “Epidemiological survey of human bird flu”, case investigation was conducted to investigate the incidence, treatment, laboratory tests, possible sources of infection, transmission routes and exposure factors. Results The initial clinical manifestations of three cases of human avian influenza were mainly flu-like symptoms. Tracheal secretions of two cases were isolated from the bird flu virus H5N1. Tracheal secretions of one case were positive for H5N1 avian influenza virus. Throat swab was found in three cases Like nucleic acid are negative. One case did not find a clear history of dead poultry contact; 2 cases had a clear history of dead poultry contact, but dead birds were not confirmed to be infected with the bird flu virus. CONCLUSIONS: All three cases are laboratory confirmed cases. Tracheal secretions samples should be collected as soon as possible. The diagnosis of human bird flu can not be based on the presence or absence of bird flu. The source of infection, transmission route and Influencing factors and other issues remain to be further studied.