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目的分析三维适形放射治疗(3DCRT)和常规放射治疗结肠癌的临床疗效。方法采用3DCRT方法(3DCRT组)辅助治疗117例结肠癌患者,每次5~6Gy,隔天照射1次,共7~8次,总剂量为40~42Gy,共照射13~15d。采用常规放射(CT组)辅助治疗102例结肠癌患者,每次2.0Gy,每周5次,总剂量为64~68Gy,共照射44~48d。比较两组患者的疗效。结果 3DCRT组患者的1、2、3和4年的局部控制率分别为75.3%、66.5%、52.7%和46.1%,CT组患者分别为55.3%、47.2%、36.5%和27.8%,两组差异有统计学意义(P<0.05)。3DCRT组患者的1、2、3和4年的生存率分别为65.2%、55.1%、45.7和40.5%,CT组患者分别为51.2%、42.5%、31.0%和24.6%,两组差异有统计学意义(P<0.05)。3DCRT组患者的血液系统反应和全身反应均较CT组轻,差异有统计学意义(均P<0.05)。结论 3DCRT能明显改善结肠癌的局部控制率和生存率,近期放射反应和远期放射损伤均可耐受。
Objective To analyze the clinical efficacy of three-dimensional conformal radiotherapy (3DCRT) and conventional radiotherapy for colon cancer. Methods A total of 117 colon cancer patients were treated with the 3DCRT method (3DCRT group), 5 to 6 Gy every time, and irradiated once every other day for 7 to 8 times with a total dose of 40 to 42 Gy for a total of 13 to 15 days. A total of 102 patients with colorectal cancer were treated with conventional radiotherapy (CT group), 2.0Gy each time, 5 times a week for a total dose of 64-68Gy for a total of 44-48 days. Compare the efficacy of two groups of patients. Results The 1, 2, 3, and 4-year local control rates of 3DCRT patients were 75.3%, 66.5%, 52.7% and 46.1% respectively. The CTCR patients were 55.3%, 47.2%, 36.5% and 27.8% The difference was statistically significant (P <0.05). The 1, 2, 3 and 4-year survival rates were 65.2%, 55.1%, 45.7 and 40.5% in the 3DCRT group and 51.2%, 42.5%, 31.0% and 24.6% in the CT group, respectively Significance (P <0.05). The patients in 3DCRT group had a lower level of blood system reaction and systemic reaction than those in CT group (all P <0.05). Conclusion 3DCRT can significantly improve the local control rate and survival rate of colon cancer, and the recent radiation and long-term radiation injury can be tolerated.