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目的：通过观察多奈哌齐联合尼莫地平片治疗VD的疗效和治疗前后MMSE、ADL评分的变化，了解其临床应用的可行性。方法选择2010.6～2013.11我科收治的脑梗死患者96例,对患者进行 MMSE量表测评，依据得分情况分为对照组（C 组）与血管性痴呆组（VD 组）,其中VD组再分为多奈哌齐联合尼莫地平治疗组（即联合治疗组）和单纯加服尼莫地平治疗组（尼莫地平组），其中联合治疗组男24例,女8例，平均78.8岁；尼莫地平组男23例,女9例，平均77.5岁；对照组男21例,女11例，平均77.3岁,三组均给予相同的活血化瘀药物等常规治疗及对症处理,联合治疗组在此基础上给予口服多奈哌齐及尼莫地平，尼莫地平组在此基础上给予口服尼莫地平,8W、12W后行MMSE 、ADL评分及计算有效率。结果8W、12W后，三组患者的MMSE 评分、ADL 评分均升高，其中，联合治疗组8W、12W后评分均高于对照组和尼莫地平组（P<0.01），尼莫地平组12W后评分高于对照组（P<0.05）。临床疗效比较,联合治疗组8W、12W后总有效率明显高于对照组与尼莫地平组（P<0.01）；尼莫地平组12W后总有效率明显高于对照组（P<0.05）。结论多奈哌齐联合尼莫地平治疗血管性痴呆疗效显著，无明显不良反应，临床中值得推广。“,”Objective The clinical curative effect observation and treatment of donepezil and nimodipine in the treatment of vascular dementia and changes of MMSE, ADL scale, to understand the feasibility of clinical application. Methods Choose 2010.6 to 2013.11 in our hospital from 62 cases of cerebral infarction patients, patients with the MMSE scale, based on scores were divided into control group (group C) and vascular dementia group (VD group), VD group was further divided into donepezil and nimodipine treatment group (i.e. combined treatment group) and simple oral nimodipine in treatment group (nimodipine group), the combined treatment group male 24 cases, female 8 cases, average 78.8 years old; nimodipine group male 23 cases, female 9 cases, average 77.5 years old; the control group male 21 cases, female 11 cases, average 74.3 years old, The three groups were given intravenous drip of Huoxue Huayu drugs and other conventional treatment and symptomatic treatment, the treatment group based on the given oral donepezil and nimodipine, nimodipine group were given oral nimodipine, 8W, 12W MMSE, ADL score for evaluation of curative effect. Results 8W, 12W, three groups of patients with MMSE score, ADL score increased, which, combined treatment group 8W, 12W scores were higher than that of control group and nimodipine group (P<0.01), nimodipine group 12W was higher than that of the control group (P<0.05). Comparison of the clinical efficacy of combined therapy group, 8W, 12W after the total efficiency was significantly higher than that in control group and nimodipine group (P<0.01);nimodipine group 12W was better than that in control group (P<0.05).Conclusion Effect of donepezil and nimodipine in the treatment of vascular dementia significantly, no significant adverse reactions, worthy of promotion in clinical therapy.