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目的综合评价胰胆管合流异常(PBM)与胆囊癌发生的关系,为胆囊癌的预防提供更多、更准确的信息。方法计算机检索中国生物医学文献数据库(CBM)、中国期刊网(CNKI)、PubMed、EMBASE、万方等数据库,检索时间从1977年4月-2011年5月,并结合文献追溯的方法,收集国内外公开发表的关于PBM与胆囊癌关系的病例对照研究或队列研究,采用RevMan 5.0.25软件进行Meta分析。结果总计纳入文献8篇,其中3篇仅对比分析了PBM在胆囊癌患者与正常对照组中发生率的差异,2篇仅对比分析了胆囊癌在PBM患者与正常对照组中发生率的差异,而另外3篇文献则对这两种发生率的差异都进行了对比。Meta分析结果显示:胆囊癌患者中PBM的发生率明显高于正常对照组,差异有统计学意义[OR=7.41,95%CI(5.03,10.87),P<0.000 01];且PBM患者中胆囊癌的发生率明显高于正常对照组,差异有统计学意义[OR=17.67,95%CI(10.43,29.94),P<0.000 01]。结论 PBM是胆囊癌发生的高危因素,与胆囊癌的发生密切相关。
Objective To evaluate the relationship between abnormal pancreaticobiliary duct (PBM) and gallbladder carcinogenesis and to provide more accurate information for the prevention of gallbladder cancer. Methods The databases of CBM, CNKI, PubMed, EMBASE and Wanfang were searched by computer. The retrieval time was from April 1977 to May 2011, and the methods of literature review were used to collect the data of domestic A published case-control study or cohort study of the relationship between PBM and gallbladder cancer, using the RevMan 5.0.25 software for meta-analysis. The results were included in the literature a total of 8, of which only 3 comparative analysis of the PBM in patients with gallbladder cancer and the incidence of the difference between the control group, 2 only comparative analysis of the gallbladder cancer in PBM patients and the control group, the incidence of differences, The other three articles compared the differences between these two rates. Meta-analysis showed that the incidence of PBM in gallbladder cancer patients was significantly higher than that of the normal control group (OR = 7.41, 95% CI 5.03, 10.87, P 0.0001) The incidence of cancer was significantly higher than that of the normal control group (OR = 17.67, 95% CI: 10.43, 29.94, P <0.0001). Conclusion PBM is a risk factor for gallbladder carcinogenesis and is closely related to the occurrence of gallbladder cancer.