8,4′-Oxyneolignane glucosides from an aqueous extract of “ban lan gen”(Isatis indigotica root)and th

• 作 者: Lingjie Meng Qinglan Guo Yufeng Liu Jiangong Shi
• 机 构: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia
• 出 处: Acta Pharmaceutica Sinica B
• 发表日期: 2017年06期
• 关键词: absolute ban lan gen Isatis erythro Cotton glycerol distinguish spectroscopic el

Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δδ_(C8-C7) values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed.

The pairs of glycosidic 8,4’-oxyneolignane diastereoisomers, named isatioxyneolignosides AF (1-6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of δδ (C8-C7) values ​​to distinguish threo and erythro aryl glycerol units and Cotton effects at 235 ± 5 nm to determine absolute configurations at C-8 in 1-6 and their aglycones (1a-6a) are discussed.