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目的 :探讨不同剂量肝素经肺给药后血药浓度变化。方法 :实验猪和慢性支气管炎 (慢支 )急性发作患者给予不同剂量肝素钠注射液 ,经气管切开和经纤支镜。定时检测给药后血药浓度。结果 :实验猪经气管内注入 1～ 8mg/ kg肝素 ,血中可检出低浓度肝素 14d,剂量与浓度无平行关系。慢支患者经纤支镜注入 10 0～ 2 0 0 mg肝素 ,血中可测出低浓度肝素 14d,剂量与浓度也无平行关系。结论 :肝素可经人肺及猪肺入血 ,不同剂量肝素 (猪 1～ 8mg/ kg,人 2～ 4m g/ kg)经肺给药后血中可检出低浓度肝素 14d。药物剂量与血药浓度无平行关系。
Objective: To investigate the changes of plasma concentration of heparin after different doses of pulmonary administration. Methods: Experimental pigs and acute exacerbation of chronic bronchitis (chronic bronchitis) were given different doses of heparin sodium injection, tracheotomy and bronchoscopy. Timing detected after administration of plasma concentration. Results: Experimental pigs were injected with 1 ~ 8mg / kg heparin through the endotracheal tube. Low concentration heparin could be detected in the blood for 14 days. There was no parallel relationship between dose and concentration. In patients with chronic bronchitis, 10 0-2 200 mg of heparin was injected via bronchofibers. Low concentrations of heparin could be detected in the blood for 14 days. There was no parallel between dose and concentration. Conclusion: Heparin can enter the blood through the lungs and lungs. Low dose heparin can be detected in the blood after 14 days of administration of different doses of heparin (pigs 1 ~ 8mg / kg, 2 ~ 4m g / kg) Drug dose and plasma concentration without parallel relationship.