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目的:观察布地奈德和特布他林联合吸入治疗喘息性疾病疗效。方法:将164例喘息性疾病患儿随机分为治疗组和对照组各82例。两组患儿均采用综合性治疗,包括吸氧、抗病毒、镇静、止咳化痰、抗感染、补充液体、纠正电解质紊乱等对症处理。对照组在综合性治疗基础上予以地塞米松+氨茶碱静脉滴注。治疗组在综合性治疗基础上应用布地奈德混悬液+特布他林加生理盐水至3～4mL,雾化吸入。两组患儿疗程均为5日。结果:治疗组总有效率为85.37%,对照组总有效率71.95%。两组患儿总有效率比较差异有统计学意义(P<0.05)。治疗后,治疗组气喘消失时间、湿性罗音消失时间、肺部哮鸣音消失时间、咳嗽消失时间均明显优于对照组,两组在上述临床症状、体征消失时间比较差异均有统计学意义(P<0.05)。两组患儿治疗后最大呼气流量与治疗前比较,均明显改善,组内治疗前后比较差异均有统计学意义(P<0.05或P<0.01)。治疗后,治疗组最大呼气流量改善程度显著优于对照组,两组比较差异有统计学意义(P<0.05)。结论:布地奈德和特布他林联合吸入治疗喘息性疾病可以提高疗效、缩短病程,值得临床推广。
Objective: To observe the curative effect of combined inhalation of budesonide and terbutaline in the treatment of asthmatic diseases. Methods: 164 cases of asthmatic children were randomly divided into treatment group and control group of 82 cases. Two groups of children were treated with comprehensive treatment, including oxygen, anti-virus, sedation, cough and phlegm, anti-infective, fluid replenishment, electrolyte disorders and other symptomatic treatment. The control group received dexamethasone + aminophylline intravenously on the basis of comprehensive treatment. Treatment group on the basis of comprehensive treatment of budesonide suspension + terbutaline plus saline to 3 ~ 4mL, inhalation. Two groups of children were treated on the 5th. Results: The total effective rate was 85.37% in the treatment group and 71.95% in the control group. The total effective rate of two groups was statistically significant difference (P <0.05). After treatment, the disappearance time of asthma, the disappearance of wet rales, the disappearance of lung wheeze, and the disappearance of cough were all significantly better in the treatment group than those in the control group. There was significant difference in the disappearance time of clinical symptoms and signs between the two groups (P <0.05). The maximum expiratory flow rate in both groups after treatment was significantly improved compared with those before treatment. There was significant difference between the two groups before and after treatment (P <0.05 or P <0.01). After treatment, the treatment group, the maximum expiratory flow was significantly better than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion: The combined inhalation of budesonide and terbutaline for the treatment of asthmatic diseases can improve the curative effect and shorten the course of the disease, which is worthy of clinical promotion.