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利用“保护氨基—接枝反应—脱保护恢复氨基”方法合成壳聚糖衍生物—羟丙基壳聚糖双胍盐酸盐(HPCGH),并将其与PVP、明胶混合制备相应的衍生物膜HPCGH-PVP,HPCGH-PVP浸没于不同浓度的碘乙醇液中得含碘膜HPCGH-PVP-I2。用FT-IR、XRD、TG和DTG对衍生物进行表征,通过碘量法测定HPCGH-PVP对碘的吸附量。碘含量分析结果表明,HPCGH-PVP吸附碘能力较强,当碘乙醇液浓度为0.03mol/L时,其对碘吸附的最大质量比为m(HPCGH-PVP)∶m(I2)=1∶0.1908。抑菌性测试结果表明,HPCGH-PVP-I2的抑菌性优于HPCGH-PVP,且HPCGH-PVP-I2对E.coli和S.aureus的敏感度均属于高度敏感。
The chitosan derivative-hydroxypropyl chitosan biguanide hydrochloride (HPCGH) was synthesized by the method of “protecting amino-grafting reaction-deprotection and recovering amino group” and mixed with PVP and gelatin to prepare the corresponding derivative Membrane HPCGH-PVP, HPCGH-PVP immersed in different concentrations of iodine ethanol solution containing iodine HPCGH-PVP-I2. The derivatives were characterized by FT-IR, XRD, TG and DTG. The iodine adsorption capacity of HPCGH-PVP was determined by iodometry. The results of iodine content analysis showed that HPCGH-PVP had a strong ability to adsorb iodine. The maximum mass ratio of iodine to HPCGH-PVP was m (I2) = 1 when the concentration of iodine-ethanol was 0.03mol / L. 0.1908. The bacteriostasis test results showed that HPCGH-PVP-I2 had better antibacterial activity than HPCGH-PVP, and the sensitivity of HPCGH-PVP-I2 to E.coli and S.aureus was highly sensitive.