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同型半胱氨酸是蛋氨酸和半胱氨酸代谢过程中一个重要的中间产物。研究发现血液中同型半胱氨酸增高,即高同型半胱氨酸血症,能够导致血管内皮损害,促进低密度脂蛋白的氧化、血小板集聚及血管平滑肌细胞增殖,从而促发动脉粥样硬化的发生。人们已经逐渐认识到它是引起心脑血管意外的独立危险因素。近年来,高同型半胱氨酸血症与冠心病,尤其是急性冠状动脉综合征的研究越来越多,然而,结果并非完全一致。遗传和环境两方面的因素共同决定了血浆同型半胱氨酸的水平,补充B族维生素可以降低血浆同型半胱氨酸的水平。
Homocysteine is an important intermediate in the metabolism of methionine and cysteine. Study found that blood homocysteine increased, that is, hyperhomocysteinemia, can lead to vascular endothelial damage, promote the oxidation of low density lipoprotein, platelet aggregation and vascular smooth muscle cell proliferation, thereby promoting atherosclerosis happened. People have come to realize that it is an independent risk factor for cardiovascular and cerebrovascular accidents. In recent years, hyperhomocysteinemia and coronary heart disease, especially acute coronary syndrome research more and more, however, the results are not exactly the same. Genetic and environmental factors together determine the level of plasma homocysteine, vitamin B supplement can reduce plasma homocysteine levels.