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由于早产机制未完全阐明,故早产发生率及早产儿发病率和死亡率一直无明显下降,感染和胎膜早破是早产的主要原因,近来研究认为感染和胎膜早破引起的早产和妊娠妇女体内基质金属蛋白酶(MMPs)的含量变化有关,这两种情况引起的早产发生前,母体血、尿及羊水中的MMPs含量将升高,从而降解妊娠组织的细胞外基质(ECM),引起胎膜破裂及宫颈成熟扩张,而导致早产,且测定妊娠妇女体内MMPs的含量变化可进行早产预测以及应用其抑制剂在动物实验中可降低早产的发生率。
As the mechanism of prematurity is not fully elucidated, the prevalence of preterm birth and morbidity and mortality of premature babies have not been significantly reduced. Infection and premature rupture of membranes is the main reason for premature delivery. Recent studies suggest that infection and premature rupture of membranes cause premature and pregnant women The level of matrix metalloproteinases (MMPs) in the body, the MMPs levels in maternal blood, urine and amniotic fluid will rise before the premature delivery caused by these two conditions, so as to degrade the extracellular matrix (ECM) of pregnant tissue and cause the fetuses Rupture of membranes, and cervical ripening and dilatation leading to premature delivery. The determination of the changes in the levels of MMPs in pregnant women can be used to predict preterm birth and the use of its inhibitors in animal experiments can reduce the incidence of preterm birth.