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用人类白细胞干扰素治疗4例慢性乙型肝炎病毒感染和慢性活动性肝炎病人,治疗前其中3例血循环中的 Dane 颗粒标志(包括与 Dane 颗粒有关的 DNA 聚合酶的活性,乙型肝炎核心抗原和 Dane 颗粒有关的 DNA)的水平持续升高,干扰素的用量为6.0×10~3～17×10~4单位/公斤体重/日,注射后3例病人的全部 Dane 颗粒标志的复制水平均迅速下降,如使用干扰素10日或少于10日,此种抑制作用为时短暂,若把治疗时间延长至1个月或更长,抑制作用看来是持久的。另外有3例病人经长期干扰素治疗,2例的乙型肝炎表面抗原明显下降。有2例病人的 e 抗原均消失。作者认为干扰素对于限制乙型肝炎病原携带者的传染性或根治慢性感染可能是有效的。本研究评价了外源性人类白细胞干扰素治疗慢性乙型肝炎病毒感染的效果。
Four human patients with chronic hepatitis B virus infection and chronic active hepatitis were treated with human leukocyte interferon (IFN). Dane particle markers (including DNA polymerase activity related to Dane particles, hepatitis B core antigen And DNA of Dane particles) continued to increase, the dosage of interferon was 6.0 × 10 ~ 3 ~ 17 × 10 ~ 4 units / kg body weight / day, all three patients after injection of Dane particles replica levels were The rapid decline, such as the use of interferon on the 10th or less, the short-term inhibitory effect, if the treatment time extended to 1 month or longer, the inhibitory effect seems to be lasting. In addition, three patients were treated with long-term interferon, and two cases of hepatitis B surface antigen decreased significantly. Two patients had e antigen disappeared. The authors believe that interferon may be effective in limiting the contagious or chronic infection of hepatitis B carriers. This study evaluated the efficacy of exogenous human leukocyte interferon in the treatment of chronic hepatitis B virus infection.