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目的探讨布地奈德吸入治疗在新生儿肺炎中的应用效果。方法将80例肺炎新生儿采用随机数字表法分为观察组和对照组,每组40例。两组均以常规治疗为基础,对照组雾化吸入氨溴索治疗,观察组在对照组的基础上吸入布地奈德,比较两组的临床疗效。结果观察组的总有效率为85.0%显著高于对照组的70.0%(P<0.05)。观察组的鼻阻、气促、肺啰音消失以及住院时间均显著少于对照组(P<0.05)。观察组治疗后的IL-6、TNF-α水平显著低于对照组(P<0.05)。结论布地奈德雾化吸入能够提高新生儿肺炎的疗效,显著改善临床症状,降低患儿的炎性因子水平。
Objective To investigate the effect of inhaled budesonide in neonatal pneumonia. Methods 80 cases of neonatal pneumonia were divided into observation group and control group using random number table method, 40 cases in each group. The two groups were based on conventional treatment, the control group inhaled ambroxol treatment, the observation group inhaled budesonide on the basis of the control group, the clinical efficacy of the two groups were compared. Results The total effective rate in the observation group was 85.0%, which was significantly higher than that in the control group (70.0%, P <0.05). Nasal resistance, shortness of breath, disappearance of pulmonary rales and hospital stay in the observation group were significantly less than those in the control group (P <0.05). The levels of IL-6 and TNF-α in the observation group were significantly lower than those in the control group (P <0.05). Conclusion Budesonide inhalation can improve the efficacy of neonatal pneumonia, significantly improve clinical symptoms and reduce the level of inflammatory cytokines in children.