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目的:对SLE与听力损失的关系进行系统性回顾分析，归纳其临床特点。方法:根据关键词检索国内外主要数据库，由作者独立提取资料并对研究文献进行质量评估。采用Review Manager 5.3和stata1 6.0统计软件对听力损失患病率、纯音听力测量（PTA）结果进行分析，在此基础上归纳听力损失的危险因素。对纳入的研究行漏斗图分析和Begg′s检验以检测发表偏倚。采用固定效应模型和随机效应模型进行Meta分析。结果:根据纳入标准和排除标准，最终纳入符合要求的观察性研究11项，Begg′s检验显示该研究无明显的发表偏倚。SLE患者听力损失患病率为26.5%，主要为感音神经性听力损失。狼疮组听力损失患病率高于对照组（n OR=4.22），PTA平均阈值在250 Hz[n MD=3.31，95%n CI（1.03，5.60），n Z=2.85，n P<0.01]，2 000 Hz[n MD=3.44，95%n CI（0.64，6.24），n Z=2.41，n P=0.02]，4 000 Hz[n MD=3.15，95%n CI（1.76，4.54），n Z=3.74，n P<0.01]，6 000 Hz[n MD=8.67，95%n CI（4.61，12.72），n Z=4.19，n P<0.01]，8 000 Hz[n MD=5.99，95%n CI（4.00，7.97），n Z=5.91，n P<0.01]时均高于对照组，尤其在6 000 Hz和8000 Hz时差值最为明显。SLE组中发生听力损失的患者补体、自身抗体、疾病活动度、病程、重要脏器损害及用药情况等与听力正常的患者进行比较，未发现听力损失与上述指标存在相关性。n 结论:SLE患者听力损失的发生率增高，多为感音神经性听力损失且主要影响高频听力，但相关危险因素仍有待进一步的研究。“,”Objective:To characterize the clinical pictures of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) through systematic review and Meta-analysis.Methods:Based on the keywords, the main databases domestic and abroad were searched, and the data were independently extracted by the authors with the quality of literature evaluated. The prevalence of HL and average threshold of pure tone audiometry (PTA) were analyzed by Review Manager 5.3 statistical software and Stata 16.0 software, and next factors related to HL in SLE were summarized. Funnel plot analysis and Begg's test were performed to detect publication bias. The fixed effect model or random effect model was used for meta analysis.Results:According to the inclusion and exclusion criteria, 11 observational or cross-sectional studies were finally included, and there was no significant publication bias in this study according to Begg's test. The prevalence of HL in SLE patients was 26.5%, among which the majority were sensorineural hearing loss. The incidence of HL in SLE patients is significantly increased compared with that in the control group (n OR=4.22), and the mean thresholds of PTA at 250 Hz [n MD=3.31, 95%n CI(1.03, 5.60), n Z=2.85, n P<0.01], 2 000 Hz [n MD=3.44, 95%n CI(0.64, 6.24), n Z=2.41, n P=0.02], 4 000 Hz [n MD=3.15, 95%n CI(1.76, 4.54), n Z=3.74, n P<0.01], 6 000 Hz [n MD=8.67, 95%n CI(4.61, 12.72), n Z=4.19, n P<0.01], 8 000 Hz [n MD=5.99, 95%n CI(4.00, 7.97), n Z=5.91, n P<0.01] was higher than that in controls (n MD=3.31, 3.44, 3.15, 8.61 and 5.99), which was more prominent at 6 000 and 8 000 Hz. When comparing patients with HL with those with normal hearing in the SLE group in terms of complement, autoanti-body, disease activity, disease course, damage of vital organs and medications, there was no correlation between HL and the above indexes.n Conclusion:The prevalence of HL in SLE patients is significantly elevated, which is mainly sensorineural and more likely to affect high-frequency listening, yet the risk factors contributed to HL in SLE remain obscure.