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目的：探讨肾病综合征（ＮＳ）患儿与其血清可溶性白介素２受体（ｓＩＬ２Ｒ）、Ｔ淋巴细胞亚群的关系。方法：采用ＥＬＩＳＡ法及ＡＰＡＡＰ法，检测２５例单纯性肾病综合征（ＳＮＳ）、２０例肾炎性肾病综合征（ＮＮＳ）患儿标本。结果：ＳＮＳ、ＮＮＳ患儿的血清ｓＩＬ２Ｒ显著高于对照组（Ｐ＜０．０１）；ＳＮＳ、ＮＮＳ之间差异也有显著性（Ｐ＜０．０１）；ＣＤ＋４细胞ＳＮＳ、ＮＮＳ较对照组明显降低（Ｐ＜０．０１）；ＣＤ＋８细胞ＳＮＳ、ＮＮＳ较对照组明显升高（Ｐ＜０．０１）。结论：ＮＳ患儿存在免疫功能异常及紊乱，其血清ｓＩＬ２Ｒ、Ｔ淋巴细胞亚群可作为ＮＳ患儿的病情监测和疗效的判断指标。
Objective: To investigate the relationship between serum soluble interleukin 2 receptor (sIL2R) and T lymphocyte subsets in children with nephrotic syndrome (NS). Methods: 25 cases of simple nephrotic syndrome (SNS) and 20 cases of nephritic nephritic syndrome (NNS) were detected by ELISA and APAAP. Results: The serum sIL2R of children with SNS and NNS was significantly higher than that of the control group (P <0.01). There was also significant difference between SNS and NNS (P <0.01). The SNS and NNS of CD + (P <0.01). The SNS and NNS in CD + 8 cells were significantly higher than those in control group (P <0.01). Conclusion: Children with NS have abnormal immune function and disorder. Serum sIL2R and T lymphocyte subpopulation may be used as indicators to monitor the disease and effect of NS in children.