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血管内皮细胞抗原是存在于血管内皮细胞、不存在于外用血淋巴细胞的一种特异性抗原。它与器官移植排异反应以及SLE、硬皮病、血管炎等自身免疫性疾病有密切关系。此外还可能与动脉粥样硬化等心血管疾病及肿瘤性疾病有关。肾移植前,如果存在血管内皮细胞抗体,不论HLA 配型是否一致,移植后均有80%的可能发生排异反应。在心脏移植排异反应中,血管内皮细胞抗原可能是主要的移植免疫原。目前,血管内皮细胞抗原的分子结构及遗传结构尚不清楚。
Vascular endothelial cell antigen is present in vascular endothelial cells, is not present in peripheral blood lymphocytes of a specific antigen. It is organ transplant rejection and SLE, scleroderma, vasculitis and other autoimmune diseases are closely related. In addition it may be related to atherosclerosis and other cardiovascular diseases and neoplastic diseases. Before renal transplantation, if there is a vascular endothelial cell antibody, regardless of HLA matching is consistent, 80% of the transplant may occur after the rejection. Vascular endothelial cell antigens may be the primary transplant immunogens in heart transplant rejection. At present, the molecular structure and genetic structure of the vascular endothelial cell antigen is not yet clear.