卵巢癌抗原CA125检测的临床价值

• 作 者: 孙树馨 韩丽霞 张健 翟羽
• 机 构: 大连医科大学附属第四医院,大连医科大学第一临床学院,大连市铁路卫生学校,鞍山市第三医院
• 出 处: 大连医科大学学报
• 发表日期: 1999年01期
• 关键词: 卵巢癌抗原 CA125检测 妇科良性肿瘤 肿瘤标记物 卵巢癌术后 卵巢癌诊断 卵巢癌细胞株 早期诊断 癌相关抗原 单克隆抗体

应用Ｅｌｉｓａ检测了１９９６年３月至１９９７年３月间本院妇科就诊患者及体检者３５６例血清中ＣＡ１２５抗原，其中卵巢癌６９例，其它癌５４例，卵巢癌术后５４例，妇科良性肿瘤５２例，其它妇科疾病３５例及正常体检者９２例。结果显示：６９例卵巢癌其ＣＡ１２５抗原检出率为８９８％（６２／６９），３５６例被测血清灵敏度测定为７６４％，特异性为８２８％，准确率达８０６％。结果提示：ＣＡ１２５抗原测定对卵巢癌的早期诊断和疗效观察有一定临床价值。

Elisa was used to detect CA125 antigen in 356 cases of gynecological patients and gynecological patients from March 1996 to March 1997, including 69 cases of ovarian cancer, 54 cases of other cancers, 54 cases of postoperative ovarian cancer, benign tumor of gynecology 52 cases, 35 cases of other gynecological diseases and 92 cases of normal physical examination. The results showed that 69 cases of ovarian cancer CA125 antigen detection rate was 89  8% (62/69), 356 cases were measured serum sensitivity was 76  4%, specificity was 82  8%, the accuracy rate of 80  6%. The results suggest that: CA125 antigen assay for early diagnosis and treatment of ovarian cancer have some clinical value.