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复发性口疮病因不明，我们发现结核变态反应为其病因之一，构成结核变态反应性复发性口疮。本文２８３例７６．３％找到结核病灶，７３．５％结核菌素试验强阳性，４７．２％免疫球蛋白ＩｇＧ增高，６７．３％抗结核抗体阳性，８４．１％皮肤结节病理和８７．５％口腔粘膜病理为变应性血管炎。提示机体细胞和体液免疫均处于高敏状态。引起口腔溃疡的机理为可溶性结核蛋白作为交叉反应性抗原，诱发机体产生自身抗体，形成抗原抗体复合物，产生结核性Ⅲ型变态反应，当体液和细胞因子聚合后，引起口腔溃疡。用抗结核剂治疗效果明显。
Recurrent aphthous etiology is unknown, we found that one of the causes of tuberculosis allergy, tuberculosis, allergic recurrent aphthous ulcers. In this paper, 76.3% of tuberculous lesions were found in 283 cases, strongly positive in 73.5% of tuberculin test, 47.2% of IgG increased, 67.3% of anti-tuberculosis antibody positive, 84.1% of pathological skin nodules and 87.5% of oral mucosal pathology is allergic vasculitis. Tip body cells and humoral immunity are in high-sensitivity state. The mechanism of mouth ulcers caused by soluble tuberculosis protein as a cross-reactive antigen, induced autoantibodies to the body to form antigen-antibody complex, resulting in tuberculous type Ⅲ allergic reaction, when the body fluids and cytokines after polymerization, causing mouth ulcers. With anti-TB treatment effect is obvious.