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目的:探讨功能性鼻内窥镜手术治疗鼻窦炎与鼻息肉的疗效。方法:选取350例鼻窦炎与鼻息肉患者,按随机数字表法分为两组,对照组(164例)给予综合疗法,观察组(186例)给予功能性鼻内窥镜手术联合综合疗法。通过观察并记录疗效,治疗前,治疗后3个月患者体内IL-1,IL-8水平,SF-36量表评分,评价功能性鼻内窥镜手术治疗鼻窦炎与鼻息肉的疗效。结果:经手术和药物治疗,观察组有效率明显高于对照组(P<0.05),治疗前,两组IL-1和IL-8水平无统计学差异(P>0.05),治疗后3个月,两组IL-1和IL-8水平均明显下降,且观察组IL-1和IL-8水平低于对照组(P<0.05),治疗前,两组SF-36各项评分无统计学差异,治疗后3个月,两组SF-36评分均明显增加(P<0.05)。观察组在躯体疼痛和总体健康2项评分明显高于对照组(P<0.05),其余6项评分相比无统计学差异(P>0.05)。结论:功能性鼻内窥镜手术对鼻窦炎与鼻息肉具有较好的疗效,能显著减轻炎症反应,改善患者生活质量,值得临床推广使用。
Objective: To investigate the efficacy of functional endoscopic sinus surgery in the treatment of sinusitis and nasal polyps. Methods: A total of 350 patients with sinusitis and nasal polyps were selected and divided into two groups according to the random number table method. The control group (164 cases) received combined therapy and the observation group (186 cases) received functional endoscopic sinus surgery combined with comprehensive therapy. The effects of functional endoscopic sinus surgery on sinusitis and nasal polyps were evaluated by observing and recording the effects of IL-1, IL-8 and SF-36 in the patients before treatment and 3 months after treatment. Results: The effective rate in observation group was significantly higher than that in control group (P <0.05). There was no significant difference in IL-1 and IL-8 levels between the two groups before treatment (P> 0.05) Month, the levels of IL-1 and IL-8 in both groups were significantly decreased, and the levels of IL-1 and IL-8 in the observation group were lower than those in the control group (P <0.05) There was significant difference in SF-36 score between the two groups at 3 months after treatment (P <0.05). The scores of body pain and general health in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in the other 6 scores (P> 0.05). Conclusion: Functional endoscopic sinus surgery for nasal sinusitis and nasal polyps has a good effect, can significantly reduce the inflammatory response and improve the quality of life of patients, it is worth promoting the use of the clinic.