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目的观察Rh血型系统IgG抗-E、抗-c引发新生儿溶血病的血型血清学表现。病例简介张某、32岁,血型BCCDee,孕三产三,第一胎健在,第二胎黄疸后遗症形成脑瘫,第三胎足月娩一子,生后16h皮肤黄染,且进行性加重。子血型为OCcDEe;夫血型为BCcDEe。结果在患儿及母血清中均查型IgG抗-E、抗-c抗体。母血清抗-E为16,子为4,母血清抗-c为4,子为2。讨论本例HDN为典型的同一丈夫Rh血型多次妊娠引起,当夫妇ABO血型相容且均有D抗原时,不容忽视Rh系统其它因子的检测,因为某种因子的不相容,都有可能引发HDN。
Objective To observe the blood group serological manifestations of Rh blood group IgG anti-E and anti-c induced neonatal hemolytic disease. Case description Zhang, 32 years old, BCCDee blood type, third trimester of pregnancy, the first child is healthy, the second child jaundice sequelae of cerebral palsy, full-term childbirth a third child, 16h after birth skin yellow dye, and progressive increase. The sub-blood type is OCcDEe; the blood type is BCcDEe. Results In both children and maternal serum were detected IgG anti-E, anti-c antibody. Mother serum anti-E is 16, son is 4, mother serum anti-c is 4, child is 2. Discussion In this case, HDN is caused by multiple pregnancies of the same husband with Rh blood type. When the couple is ABO-compatible and all have D antigen, the detection of other factors in the Rh system can not be ignored because of the incompatibility of certain factors Lead to HDN.