加铬砷酸铜和五氯酚铜铬木材防腐剂的致突变性研究

• 作 者: 施红生 王东黎
• 机 构: 铁道部劳动卫生研究所工业毒物研究室,铁道部劳动卫生研究所工业毒物研究室,
• 出 处: 铁道劳动安全卫生与环保
• 发表日期: 1987年03期
• 关键词: 木材防腐剂 砷酸铜 五氯酚 突变性 急性毒性实验 致突变物 重铬酸盐 经口 大鼠 致突变作用

加铬砷酸铜(CCA)、五氯酚铜铬(PCCA)制剂是近两年来新研制的木材防腐剂。CCA原液的浓度为30％,其配方为As_2O_5·2H_2O11％、CuSO_4·5H_2O33％、Na_2Cr_2O7·2H_2O56％。PCCA制剂含CuSO_450％、Na-PCP25％、Na_2Cr_2O_725％。急性毒性实验结果:CCA大、小鼠经口LD_(50)分别为227.282mg/kg,大鼠经皮LD_(50)为156mg/kg;PCCA大、小鼠经口LD_(50)分别为542、1656mg/kg。许多研究证实,无机砷化合物、重铬酸盐为致突变物,流行病学调查表明,无机砷可引起肺

Chromium arsenate (CCA), copper pentachlorophenate (PCCA) preparation of the last two years the newly developed wood preservatives. The concentration of CCA stock solution is 30%, and the formulation is As_2O_5 · 2H_2O11%, CuSO_4 · 5H_2O33% and Na_2Cr_2O7 · 2H_2O56%. PCCA preparation containing CuSO_450%, Na-PCP25%, Na_2Cr_2O_725%. The results of acute toxicity test showed that the oral LD ​​50 of CCA and Mice were 227.282 mg / kg and the LD 50 of rats were 156 mg / kg, and the LD 50 of mice with PCCA were 542 , 1656 mg / kg. Many studies confirm that inorganic arsenic compounds, dichromate as a mutagen, epidemiological investigations showed that inorganic arsenic can cause lung