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目的观察中药分期论治验方治疗儿童哮喘的临床疗效。方法 75例哮喘患儿随机分为中药组45例和西药组30例,另选正常组10例。中药组急性发作期予射干2号合剂,每次10ml,每日3次,7天为1个疗程;缓解期予黄芪补肾合剂为主随症加减治疗3个月。西药组急性发作期予爱纳灵1/2片或1片,每日2次,7天为1个疗程,缓解期予顺尔宁4～5mg,每日1次,治疗3个月。治疗前后对两组患儿进行中医证候评分和西医症状评分,并对中药组和西药组部分患儿和正常组进行肺功能检测。结果两组患儿治疗后中医主要症状积分和总积分、西医主要症状积分和总积分均较治疗前明显降低(P<0.01);治疗后西药组患儿鼻部症状评分低于中药组(P<0.05)。中药组在治疗后通气功能各指标与治疗前比较均有明显改善(P<0.05),且基本达到正常组水平(P>0.05),其中用力肺活量(FVC)的提高优于西药组(P<0.05)。中药组治疗后的肺潮气呼吸、气道阻力中的多项指标得到改善(P<0.05)。结论中药分期论治验方能有效控制哮喘患儿的哮喘发作症状、改善肺功能。
Objective To observe the clinical efficacy of traditional Chinese medicine staging on the treatment of childhood asthma. Methods Seventy-five children with asthma were randomly divided into 45 cases in the traditional Chinese medicine group and 30 cases in the western medicine group, and 10 cases in the normal group. Acute exacerbation of Chinese medicine group to injection No. 2 mixture, each 10ml, 3 times a day, 7 days for a course of treatment; remission to Astragalus Bushenzheyin mainly with the addition and subtraction of the disease for 3 months. Acute episodes of Western medicine group to Anermide 1/2 or 1, 2 times a day, 7 days for a course of treatment, remission to 4 ~ 5mg Shunde Ning, 1 day, treatment for 3 months. Before and after treatment, TCM syndrome scores and Western medicine symptom scores were evaluated in both groups. Pulmonary function tests were performed on some children in traditional Chinese medicine group and western medicine group and normal group. Results After treatment, the main symptom scores and total scores of Chinese medicine and the scores of main symptoms and scores of Western medicine were significantly lower than those before treatment (P <0.01). After treatment, the score of nasal symptoms in children with Western medicine was lower than that of traditional Chinese medicine (P <0.05). After treatment, the indexes of ventilatory function of TCM group were significantly improved (P <0.05), and reached the level of normal group (P> 0.05). The improvement of FVC was better than Western medicine group (P < 0.05). The number of indicators of lung tidal respiration and airway resistance after treatment in TCM group improved (P <0.05). Conclusion The traditional Chinese medicine staging theory can effectively control asthma in children with asthma attack symptoms and improve lung function.