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研究背景 尽管雄激素一直以来被认为是心血管系统的不利因素之一 ,然而近年来的实验研究资料提示 ,睾酮可能对心肌缺血或再灌注损伤后功能的恢复有良性作用 .因此 ,本研究目的在于明确睾酮是否通过激活线粒体及 /或肌浆内ATP -敏感的钾通道增加心肌细胞对缺血的耐受性 .方法与
BACKGROUND Although androgens have long been considered as one of the unfavorable factors of the cardiovascular system, experimental data from recent years suggest that testosterone may have a beneficial effect on the recovery of function after myocardial ischemia or reperfusion injury.Therefore, this study The purpose of this study was to determine whether testosterone increases cardiomyocyte tolerance to ischemia by activating ATP - sensitive potassium channels in mitochondria and / or sarcoplasm.Methods