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运用国产试剂盒对47例儿童肾脏病患者及15例正常健康儿进行血浆 D-二聚体和血 FDP 测定并对15例。肾病患儿在应用抗凝治疗前后作动态检测。结果不同。肾病患儿血 D-二聚体值均高于正常儿组,其中以肾病组升高更为显著(P<0.01);15例肾病患儿动态检测结果表明经过抗凝治疗后血 D-二聚体值下降并接近正常。结果提示:在无临床栓塞表现的儿童肾脏病测定 D-二聚体可间接预测高凝状态存在,并可作抗凝药物治疗的依据和预后估计。
47 cases of children with kidney disease and 15 cases of normal healthy children were tested by D-kit and FDP in 15 cases. Children with nephropathy before and after the application of anticoagulant therapy for dynamic detection. The result is different. D-dimer levels in children with nephropathy were higher than those in normal children, especially in nephropathy group (P <0.01). The results of dynamic examination in 15 children with nephropathy showed that after D-dimer The mer is lower and closer to normal. The results suggest that the determination of D-dimer in pediatric nephropathy without clinical embolism may indirectly predict the existence of hypercoagulable state and may be used as the basis and prognosis of anticoagulant therapy.