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目的:观察托烷司琼预防含顺铂化疗药物所致恶心、呕吐的疗效和不良反应。方法:将入选62例接受含顺铂联合化疗的恶性肿瘤患者,随机分成两组,观察组32例病人于化疗前使用托烷司琼止吐,对照组30例病人使用昂丹司琼。观察两组病人恶心、呕吐的控制情况及不良反应。结果:托烷司琼和昂丹司琼预防化疗后恶心、呕吐的有效率无明显差异(P>0.05);但完全控制率托烷司琼优于昂丹司琼(P<0.05)。两组不良反应发生率无明显差异。结论:托烷司琼能有效预防含顺铂化疗药物所致恶心、呕吐,安全性好。
Objective: To observe the efficacy and adverse reactions of tropisetron in preventing nausea and vomiting induced by cisplatin-containing chemotherapy drugs. Methods: Sixty-two patients with malignant tumors treated with cisplatin combined with chemotherapy were randomly divided into two groups: 32 patients in the observation group received tropisetron before chemotherapy and 30 patients in the control group received ondansetron. Two groups of patients were observed nausea and vomiting control and adverse reactions. Results: The efficacy of tropisetron and ondansetron in the prevention of nausea and vomiting after chemotherapy had no significant difference (P> 0.05). However, the complete control rate of tropisetron was better than that of ondansetron (P <0.05). No significant difference in the incidence of adverse reactions between the two groups. Conclusion: Tropisetron can effectively prevent nausea and vomiting caused by cisplatin-containing chemotherapy drugs and is safe.