【摘 要】
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Dear Editor,Aging is the leading risk factor for many chronic diseases,accounting for almost 60％ of all deaths worldwide.How to achieve healthy aging,alleviate a
【机 构】
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Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatr
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Dear Editor,Aging is the leading risk factor for many chronic diseases,accounting for almost 60％ of all deaths worldwide.How to achieve healthy aging,alleviate aging-related diseases,and extend healthspan has become a main topic of biomedical research (He et al.,2019).Geroprotective compounds,such as mefformin and rapamycin,have been shown to improve both healthspan and lifespan in mice (Martin-Montalvo et al.,2013;Bitto et al.,2016),whereas nicotinamide partially improves healthspan in mice (Mitchell et al.,2018).In addition,senolytics,compounds that eliminate senescent cells,have been proven to improve physical function and increase lifespan in mice (Xu et al.,2018).Although none have proven to be clinically reliable in delaying aging or treating frailty in humans,these compounds have already provoked enthusiasm for identifying a potential "elixir".Therefore,the exploration of more geroprotective compounds,especially natural active compounds,holds great potential for the development of geriatric medicines.
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