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目的研究碱性髓鞘蛋白(MBP)与脑出血破入脑室患者病情预后的关系。方法选取2002￣2005年我院脑出血破入脑室住院病人30例,分别于脑出血后12h和第3、7、21天采集外周静脉血进行MBP检测,根据患者脑出血后2个月格拉斯哥预后评分(GOS)分为预后不良组和预后良好组。体检正常者15例为正常对照组进行MBP检测。结果脑出血破入脑室患者出血后血清MBP浓度显著高于正常对照组,其浓度随时间的推移呈下降趋势,但仍高于正常对照组;预后不良组出血后MBP浓度在检测时间点持续高于预后良好组,且有统计学差异(P<0.01)。结论MBP的浓度与脑出血破入脑室患者的预后有一定的相关关系,MBP浓度越高,其预后越差。
Objective To investigate the relationship between the prognosis of patients with cerebral hemorrhage and ventricular involvement of basic myelin protein (MBP). Methods Thirty patients with intracerebral hemorrhage admitted to our hospital from 2002 to 2005 were enrolled in this study. Peripheral venous blood was collected at 12 and 3, 7 and 21 days after intracerebral hemorrhage for MBP. According to the prognosis of Glasgow two months after intracerebral hemorrhage Score (GOS) is divided into poor prognosis group and good prognosis group. Normal physical examination in 15 cases of normal control group MBP test. Results The concentration of serum MBP in patients with intracerebroventricular hemorrhage after ICH was significantly higher than that of the normal control group. The concentration of MBP decreased with the passage of time but was still higher than that of the normal control group. The MBP concentration in the poor prognosis group was persistently high at the detection time Good prognosis group, and there was a significant difference (P <0.01). Conclusions The concentration of MBP has a certain correlation with the prognosis of patients with cerebral hemorrhage who have penetrated into the ventricle. The higher the concentration of MBP, the worse the prognosis.