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目的探讨MTRRA66G、MSD919G、MTHFRC677T基因多态性与脑梗死的关系。方法选择136例脑梗死(CI)患者和70例对照,用PCR-RFLP方法分析其MTRR、MS和MTHFR基因型。结果CI组和对照组的MTRRA66G多态性的分布差异无显著性意义(χ2=1.645,P=0.439);CI组与对照组相比,MSD919G各基因型的频率差异无显著性意义(χ2=1.040,P=0.595);两组的MTHFRC677T各基因型的频率差异也没有显著性意义(χ2=1.399,P=0.497)。结论通过实验推测MTRRA66G、MSD919G、MTHFRC677T基因多态性不是CI的独立遗传危险因素。
Objective To investigate the relationship between MTRRA66G, MSD919G and MTHFRC677T gene polymorphisms and cerebral infarction. Methods 136 patients with cerebral infarction (CI) and 70 controls were selected and their MTRR, MS and MTHFR genotypes were analyzed by PCR-RFLP. Results There was no significant difference in the distribution of MTRRA66G polymorphism between CI group and control group (χ2 = 1.645, P = 0.439). There was no significant difference in genotype frequencies of MSD919G between CI group and control group (χ2 = 1.040, P = 0.595). There was no significant difference in the frequencies of MTHFRC677T genotypes between the two groups (χ2 = 1.399, P = 0.497). Conclusions The MTRRA66G, MSD919G and MTHFRC677T gene polymorphisms were not found to be independent genetic risk factors of CI by experiment.