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本实验研究了放射损伤、烧伤与放烧复合伤后血清成份对培养心肌细胞Ｌ－型钙离子通道活动的影响，结果表明：伤后血清对上述通道均有激活作用，从而改变细胞内钙离子水平，此可能为伤后心脏功能抑制的一个重要机理。在作用强度上，复合伤血清重于单一伤、烧伤重于放射损伤，这是导致不同伤后血清对心功能抑制程度不一的重要因素。对伤后血清成分作用的进一步研究表明：伤后血清大分子的作用不明显，主要是血清低分子与血清脂质起作用。其中，放烧复合伤血清低分子不仅使通道开放增加，还使膜片噪声增加，提示其作用包括改变其Ｌ－型钙离子通道活动与改变膜的物理特性二个方面，它们共同导致细胞的功能变化；血清脂质对钙通道的作用可被ＳＯＤ所抑制，表明其作用与氧自由基反应有关。至于伤后血清低分子与血清脂质中的具体毒性成分以及它们对Ｌ－型钙离子通道影响的调控机制，有待于进一步研究
The experimental study of radiation injury, burns and burn combined with serum composition of cultured myocardial cells L-type calcium channel activity, the results showed that: after injury, serum on the above channels have an activation effect, thereby changing the intracellular calcium Level, which may be an important mechanism of cardiac function inhibition after injury. In the role of intensity, composite wound heavier than a single injury, burns heavier than radiation damage, which is caused by different serum levels of heart function inhibition of different factors. Further studies on the role of post-injury serum components show that the role of serum macromolecules after injury is not obvious, mainly due to the effect of serum low molecules and serum lipids. Among them, the combination of burn and burn serum low molecular weight not only increased the opening of the channel, but also increased the noise of the patch, suggesting that its effects include changing its L-type calcium channel activity and changing the physical properties of the membrane in two aspects that together lead to cellular Function changes; the role of serum lipid on calcium channels can be inhibited by SOD, indicating that its role and oxygen free radical reaction. As for the post-injury serum low molecular weight and serum lipid in the specific toxic components and their effects on L-type calcium channel regulation mechanism needs further study