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目的检测系统性红斑狼疮(systemic lupus erythematosus,SLE)患者外周血中趋化因子CXCL9,CXCL10及CXCL11的表达情况并探讨其与临床特征的关系。方法采用ELISA法检测32例SLE患者及10例健康对照血清中CXCL9,CXCL10及CXCL11的表达情况,并将其与相应临床症状及实验室结果进行统计学分析。结果 SLE患者血清中CXCL9,CXCL10及CXCL11表达均明显高于健康对照(P均<0.05),且在中、重度活动期组血清中的表达明显高于轻度活动期组及稳定期组(P均<0.05);CXCL9,CXCL10及CXCL11表达强度与补体C3呈负相关(P均<0.05),与补体C4,ESR,CRP及24h尿蛋白定量均无相关性;CXCL9,CXCL10在有肾脏受累的患者中明显升高(P均<0.05),关节炎患者中CXCL10表达明显升高(P<0.05);此外,在抗SM抗体阳性患者中CXCL9表达显著升高(P<0.05),抗ds DNA抗体及抗核小体抗体阳性患者中CXCL10表达显著升高(P均<0.05)。结论 CXCL9,CXCL10及CXCL11表达与SLE活动性及严重程度有关,可能在SLE发病中发挥作用。
Objective To detect the expression of chemokines CXCL9, CXCL10 and CXCL11 in the peripheral blood of patients with systemic lupus erythematosus (SLE) and to explore its relationship with clinical features. Methods The expressions of CXCL9, CXCL10 and CXCL11 in 32 SLE patients and 10 healthy controls were detected by ELISA. The clinical symptoms and laboratory results were analyzed statistically. Results The serum levels of CXCL9, CXCL10 and CXCL11 in SLE patients were significantly higher than those in healthy controls (all P <0.05), and the levels of CXCL9, CXCL10 and CXCL11 were significantly higher in moderate and severe active stage than in mild active stage and stable stage (All P <0.05). The expressions of CXCL9, CXCL10 and CXCL11 were negatively correlated with complement C3 (all P <0.05), but not with the levels of complement C4, ESR, CRP and urinary protein 24 h (P <0.05). The expression of CXCL10 was significantly increased in patients with arthritis (P <0.05). In addition, the expression of CXCL9 was significantly increased in anti-SM antibody-positive patients (P <0.05) The expression of CXCL10 was significantly increased in both antibody and anti-nucleosome antibody-positive patients (all P <0.05). Conclusion The expressions of CXCL9, CXCL10 and CXCL11 are related to the activity and severity of SLE and may play a role in the pathogenesis of SLE.