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麝香酮(Muscone)是麝香(Moschus)主要有效成分之一,在药理上具有兴奋作用,其含量为0.5～3.28％,我们对豨莶通栓丸中麝香酮提取分离后,利用薄层扫描法定量,方法简单、迅速、准确,图谱清晰,是控制含麝香药物质量的可行方法。 1 材料与试药 ①材料 豨莶通栓丸由抚松制药厂提供。处方中麝香含量为0.236％。②试药 麝香酮标准品(dl-3-甲基十五环酮,卫生部生物制品检定所)浓度2.0mg/ml无水乙醇溶液,2,4一二硝基苯肼试液(临时配制),基余试剂均为分析纯。 2 样品溶液及标准溶液的配制 ①样品溶液的配制 准确称取豨莶通栓丸25g 3份,分别置于索氏提
Muscone is one of the main active ingredients of Moschus and has pharmacologically stimulatory effects. Its content is 0.5 to 3.28%. After the extraction and separation of muscone in Qi Tong Tong Suan Pill, thin layer scanning is used. Quantitative, simple, rapid, accurate, clear map, is a feasible method to control the quality of the drug containing musk. 1 Materials and reagents 1 Materials Qintong Suppositories are provided by Fusong Pharmaceutical Factory. The content of musk in the prescription is 0.236%. 2 reagents musk ketone standards (dl-3-methylpentacyclopentane, Ministry of Health Biological Products Institute) concentration 2.0mg/ml absolute ethanol solution, 2,4-dinitrophenylhydrazine test solution (temporary preparation The rest of the reagents are of analytical grade. 2 Preparation of sample solution and standard solution 1 Preparation of sample solution Accurately weigh and take 25g of gutongtong bolus, and place them in Soxh.