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目的研究HLA抗体的产生与孕妇妊娠次数的关系。方法选择2016年11月9日-2017年3月31日在邵逸夫医院下沙院区登记待产的24-28周856例孕妇为研究对象,收集其外周血血样,利用单克隆抗体固相血小板抗体实验检测孕妇血清中HLA抗体的表达情况。结果共检出HLA抗体阳性孕妇67例,抗体阳性率为7.8%。334例首次妊娠的孕妇中,有15例HLA阳性的,阳性率为4.5%;216例无流产史的两次或以上妊娠的孕妇中,有14例阳性,阳性率为6.5%;107例有一次流产史的孕妇中,有10例阳性,阳性率为9.3%;223例有两次及以上流产史的孕妇中,有28例阳性的,阳性率为12.6%。妊娠次数与HLA抗体发生率呈正相关。结论二次及以上妊娠的孕妇HLA抗体发生率高于首次妊娠的孕妇。
Objective To study the relationship between the generation of HLA antibodies and the number of pregnant women. METHODS: A total of 856 pregnant women, 24-28 weeks old, who had been registered as non-pregnant women in the Xiasha hospital area of Run Run Shaw Hospital from November 9, 2016 to March 31, 2017 were enrolled in this study. Blood samples were collected from peripheral blood samples. Monoclonal antibody solid phase platelet antibody Experimental detection of pregnant women serum HLA antibody expression. Results A total of 67 HLA-positive pregnant women were detected, the positive rate of antibody was 7.8%. Among the 334 pregnant women who had the first pregnancy, 15 were HLA-positive and the positive rate was 4.5%. Of the 216 pregnant women with two or more pregnancies without pregnancy history, 14 were positive and the positive rate was 6.5% Among the pregnant women with a history of miscarriage, 10 were positive and the positive rate was 9.3%. Of the 223 pregnant women who had two or more abortions, 28 were positive and the positive rate was 12.6%. The number of pregnancy and the incidence of HLA antibodies was positively correlated. Conclusions The incidence of HLA antibodies in pregnant women of the second or more pregnancies is higher than that of the first pregnancies.