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报道3例多爱卵巢综合征（polycysticovarysyndrome，PCOS）患者用克罗米酚（clomiphenecitrate，CC）及人绝经期促性腺激素（humanmenopausalgonadotropin，hMG）促排卵失败，而采用促性腺激素释放激素激动剂（gonadotropinreleasinghormoneagonist，GnRH－a）长期脱敏万案。达到垂体抑制后联合用hMG-人绒毛膜促性腺激素（hCG）促排卵。3例患者各治疗1周期，2例妊娠，1例继续治疗。结果表明：对传统的hMG促排卵疗法无效的PCOS患者，选用GnRH－a联合hMG可获得较好效果；采用GnRH－a长期脱敏万案可减轻卵巢过度刺激综合征（ovarianhyperstimulationsyndrome，OHSS）的发生，减少治疗作废率；但是PCOS患者需用较长时间的GnRH－a才能达到垂体抑制；用GnRH－a＋hMG＋hCG诱导排卵后可出现黄体功能不足，应给hCG或孕酮支持黄体。
Reported the failure of ovulation induction by clomiphene citrate (CC) and human menopausal hormone (hMG) in 3 patients with polycystic ovarysyndrome (PCOS), but failed to promote ovulation by using gonadotropin-releasing hormone agonist gonadotropinreleasinghormoneagonist, GnRH-a) long-term desensitization program. Pituitary suppression combined with hMG-human chorionic gonadotropin (hCG) ovulation. Three patients had one cycle of treatment, two cases of pregnancy and one case of continuous treatment. The results showed that GnRH-a combined with hMG could achieve good results in patients with PCOS who had no effect on traditional ovulation induction therapy of hMG ovarian hyperstimulation. The long-term desensitization of GnRH-a could alleviate the occurrence of ovarian hyperstimulation syndrome (OHSS) , But reduce the treatment rejection rate; However, PCOS patients need longer GnRH-a to achieve pituitary inhibition; GnRH-a + hMG + hCG induced ovulation may appear luteal function, should support hCG or progesterone luteal.