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目的观察腺梗豨莶ⅡA对深静脉血栓形成大鼠血红素氧合酶-1活性的影响。方法 60只SD大鼠随机分为正常对照组、模型对照组、阿司匹林组、肝素组、腺梗豨莶ⅡA高剂量组、腺梗豨莶ⅡA低剂量组,采用环形缩窄下肢股静脉管腔1/2限流,直流电持续电击损伤造下肢深静脉血栓模型,缝合腹壁6 h后重新打开,剥离静脉取出血栓称湿重及干重,并采用分光光度法检测HO-1活性。结果腺梗豨莶ⅡA对结扎并电击损伤管壁造成的股静脉血栓的重量有明显减轻作用并能诱导HO-1活性增加,与模型组比较差异有统计学意义(P<0.01)。结论腺梗豨莶ⅡA能诱导HO-1表达,保护血管内皮细胞功能,起到抗血栓的作用。
Objective To observe the effect of Adenocarcinoma Ⅱ A on heme oxygenase-1 activity in rats with deep venous thrombosis. Methods Sixty Sprague-Dawley rats were randomly divided into normal control group, model control group, aspirin group, heparin group, high-dose Ⅱ A group, low-dose group Ⅱ A, 1/2 current, DC continuous electric shock damage caused by deep vein thrombosis model, suture the abdominal wall after 6 h and reopened, stripped venous thrombolysis said wet weight and dry weight, and the detection of HO-1 activity by spectrophotometry. Results Adenocarcinoma 豨 莶 Ⅱ A significantly reduced the weight of femoral vein thrombosis caused by ligation and electric shock injury and induced an increase in HO-1 activity, with statistical significance compared with model group (P <0.01). Conclusions Adenocarcinoma 豨 莶 Ⅱ A can induce HO-1 expression, protect the function of vascular endothelial cells, and play an antithrombotic effect.